When 31-year-old real estate appraiser Mike Williams mysteriously vanishes while duck hunting in the Florida swamps in December of 2000, authorities suspect his life was ended by alligators but was the story unfolds, an unexpected suspect rises to the top... his wife. Cold Case Files investigates the pursuit and resolution of long-unsolved cases. The episodes follow the detectives and the family members whose undying devotion is the difference between bringing justice to the crime victims and having their loved ones lost in the drawers of the cold case files. From the story of a criminal's childhood memory of his sister's death, to the use of mass DNA testing to find a killer, these detectives find the clues to solve crimes as many as 30 years old, and bring the guilty to justice.