Suspicious Minds follows the Victorian Institute of Forensic Medicine's investigators as they help solve brutal murders and perplexing unexplained deaths. Most cases are resolved by forensic investigators within the laboratories of the institute, but some are followed all the way to the Coroner's Court.

Beyond Australian shores, the institute's pathologists play a pivotal role in forensic investigations such as those surrounding the Asian tsunami disaster, the murder trial of former militant leader Harold Keke in the Solomon Islands, and the exhumation of mass graves in East Timor.

Dramatic national and international stories are counter-pointed by fascinating scientific initiatives undertaken by the pathologists at all levels. The series' examines the human desire to see mysteries solved and justice served highlighting the fragility of life.