Middle School teacher Donna Boley is overcome with nausea and a tingling feeling in her extremities. The principal finds Donna crawling up the stairs on her hands and knees. He tells her to go home. At home, Donna's husband, Jim, tries to nurse her back to health. They believe she might have caught something during their recent vacation in Missouri. For the next week, Donna is sick in bed. Her symptoms worsen and she is rushed to a local hospital.

There she begins to have seizures, which persist throughout the night. By morning, she crashes and slips into unconsciousness. Baffled, doctors review her charts. They notice that she has an extensive medical history. She has prior diagnoses of irritable bowel syndrome, an ovarian cyst that left her unconscious for two weeks and lupus. Now she is paralyzed from the nose down. Doctors decide to perform a heavy metals screen and it is determined that Donna is being poisoned. She is moved to another area of the hospital and classified as a Jane Doe for her protection. Investigators use a letter board to communicate with her.

She tells them she fears her husband might have something to do with her illness. Investigators meet with Jim and he confesses to making her sick. Jim, her loving and devoted husband, has been poisoning her all along with rat poison bought on their vacation to Missouri.