In Las Vegas, Detectives Mike Wallace and Mark McNett are called out on a nightmare of a case: a beautiful young woman was assaulted and murdered in her own apartment. With nothing but the physical evidence, they have to find out if the killer is a total stranger or someone she knows.

In Miami, Detectives Rolly Garcia and Orlando Silva must track down an enormous handgun that was used to gun a man down on a residential sidewalk; the .50 caliber Desert Eagle is such a rare weapon that the Miami crime lab has never handled a case with one before.